Combining Laser Interstitial Therapy With Immunotherapy: Rationale for a Clinical Trial


Gavin Dunn, MD, Assistant Professor of Neurological Surgery and Director of Brain Tumor Immunology and Therapeutics at Washington University School of Medicine discusses combining laser interstitial thermal therapy (LITT) with immunotherapy and the rationale for a clinical trial. He begins by providing a short overview of LITT, the applicable indications and biological effects. He then delves into the ongoing clinical trials in this area before moving on to the arguments for combining LITT with immunotherapy. Finally, he reviews the study that he and his colleagues are completing titled “MK-3475 in Combination with MRI-guided Laser Ablation in Recurrent Malignant Gliomas”.


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