Mature Results of a Phase I SRS Dose Escalation Trial in Combination with an EGFR Inhibitor Gefitinib in Recurrent Malignant Gliomas and a Follow-up Pilot Trial with an EGFR and VEGFR Dual Inhibitor

Event: 4th International Conference of the Novalis Circle 2008
Topic: Cranial neoplasia - benign
Year: 2008

Changhu Chen, MD, from the University of Colorado Denver discusses the mature results of a phase I SRS dose escalation trial in combination with an EGFR inhibitor gefitinib in recurrent malignant gliomas and a follow-up pilot trial with an EGFR and VEGFR dual inhibitor. Before he goes into detail about these trials, their methods and results, he gives some background about recurrent malignant gliomas and their treatment.

Video Transcript

Good morning, everybody. Before I get started, I just want to point out that the definition of SRS used over here is the new, recently ASTRO-endorsed definition that, still technically localized high dose radiation up to 5 fractions. So, over here I'm not talking about a single fraction, stereotactic radiosurgery, you know, we use 3 fractions. This is a report of our phase 1 study to combine this stereotactic radiosurgery called the fractionated stereotactic radiosurgery with a EGFR inhibitor called gefitinib or Iressa in the patient with recurrent astrocytoma, or the GBM. As we know that the recurrent malignant gliomas,...

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