Amol J. Ghia, MD, Radiation Oncologist at the University of Texas M.D. Anderson Cancer Center discusses 6D setup and monitoring for spine radiosurgery (SRS) treatments. He begins by presenting a few illustrative cases before delving into the critical factors of SRS setup, most specifically alignment facilitated by immobilization and image guidance. He then goes through his institution’s workflow for planning, patient immobilization and intrafractional position verification. Dr. Ghia discusses a prospective validation of treatment accuracy using implanted fiducial markers for spinal stereotactic body radiation therapy (SBRT). Finally, he discusses ExacTrac Dynamic in terms of real-time motion monitoring, its new features and compares it to ExacTrac X-Ray.