Nzhde Agazaryan, PhD, Professor of Radiation Oncology at the University of California Los Angeles discusses the impact of margins for single isocenter multiple brain metastases radiosurgery treatments. He begins by outlining their commissioning and validation of this methodology as well as patient-specific quality assurance methods. He first outlines the time saved with the software as tracked by his team versus previous planning software, before delving into how margins impact total target volumes and why his institution is now striving to reduce margins.